ATSDR/CDC Multi-site Study

In September 2019, the Centers for Disease Control and Prevention (CDC) and the Agency for Toxic Substances and Disease Registry (ATSDR) established cooperative agreements with seven partners to study the human health effects of exposure to PFAS through drinking water at locations across the nation. As one of the seven partners, Silent Spring Institute is focusing on two communities in Eastern Massachusetts—Hyannis and Ayer—where public drinking water supplies have been contaminated by PFAS from the use of firefighting foams at nearby fire training areas.

The goal is to learn more about the relationship between PFAS (per- and polyfluoroalkyl substances) and health outcomes among differing populations. Silent Spring is leading the five-year study in collaboration with Harvard T.H. Chan School of Public Health and Eastern Research Group. The community partners include People of Ayer Concerned about the Environment (PACE) and Massachusetts Breast Cancer Coalition (MBCC).

The team will collect blood samples from 1000 adults and 300 children. The study’s aims are to:

  • Evaluate blood concentrations of PFAS and associations with immunological, metabolic, and reproductive effects, and neurobehavioral outcomes in children.
  • Use analytical methods to measure total PFAS exposure (including unknown PFAS) and use non-targeted metabolomics and molecular networking to identify these additional PFAS compounds.
  • Evaluate associations between PFAS exposures and novel markers of elevated disease risks, such as lipoproteins, metabolomics markers of lipid metabolism, body fat, and antibody levels.

Results from the study will be used to develop health-based standards for drinking water and provide new insight into the full set of PFAS that are commonly found in people’s bodies.

Read more about the ATSDR Multi-Site Health Study here and the CDC/ATSDR study announcement here.